Associate Scientist I, CAR Screening and Discovery

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies, is recruiting for an Associate Scientist I, CAR Screening and Discovery based in Spring House, Pennsylvania.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal.   Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Cell Therapy team at Janssen Therapeutics Discovery seeks a lab-based, highly motivated Associate Scientist to join our Chimeric Antigen Receptor (CAR) Screening and Discovery team. The Associate Scientist I will join a cross-functional group of experts building a high throughput CAR screening pipeline for autologous and iPSC-derived effector cell types. The ideal candidate is an organized, self-driven scientist that thrives in a collaborative team-based environment, is excited to learn and has experience setting up in vitro functional assays to measure T cell function using both representative cell lines and primary human cells. Demonstrated expertise in multi-color flow cytometry is essential. Key activities will include optimizing and executing immune cell-based assays for high throughput screening of CAR candidates, collecting, and analyzing multiparameter flow cytometry data, cell line maintenance, and assisting in the processing/management of high-volume data.

Primary responsibilities:

• Design and execute experiments based on protocols
• Analyze and interpret experimental data
• Actively participate in troubleshooting of routine problems related to continuous improvement or development of new approaches/technologies
• Coordinate experimental activities with other team members to deliver results that meet pre-defined timelines
• Assist in CAR T cell generation, expansion, characterization, and cryopreservation
• Thaw and culture a variety of mammalian cell lines using aseptic technique
• Maintain a thorough, accurate, complete, and up-to-date laboratory notebook
• Data generation, analysis, maintenance, and communication to immediate team and cross-functional teams