Posdoctoral Fellow - Immunology

At Johnson & Johnson, we use technology and the power of teamwork to discover new ways to prevent and overcome the world’s the most significant healthcare challenges. Our Corporate, Consumer Health, Medical Devices, and Pharmaceutical teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're disrupting outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there’s no limit to the impact you can make here. Are you ready to reimagine healthcare?

Here, your career breakthroughs will change the future of health, in all the best ways. And you’ll change, too. You’ll be inspired, and you’ll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us!

Janssen Research and Development, L.L.C., a member of Johnson and Johnson's Family of Companies, is recruiting for a Postdoctoral Fellow, to be located in San Diego, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The ImmunoDermatology group in the Immunology Translational Sciences department is searching for a highly motivated, creative and collaborative postdoctoral fellow to advance our understanding of IL-23 biology in health and disease. This is an exciting opportunity to investigate the role of IL-23 producing cells using patient specimens. The postdoctoral fellow will be skillful in crafting in vitro and ex vivo functional characterization of human dendritic cells by flow cytometry, immunofluorescence and transcriptional analysis. They will analyze clinical trial samples to investigate the pharmacodynamic response to guselkumab, an IL-23 inhibitor. The successful candidate will engage in the planning, execution, and interpretation of laboratory experiments, such as assay optimization and development, data collection, data QC and data analysis. They will be conducting experiments with limited guidance and will be encouraged to collaborate with bioinformaticians and lab scientists to conduct multi-omic analysis. The candidate will also evaluate and optimize method for novel platforms to enable multiparameter analysis of patient derived samples. This will be an opportunity for career development and growth and potential publications.

RESPONSIBILITIES ARE AS FOLLOWS:

• Crafting, performing and interpreting ex vivo experiments with primary human tissue and immune cells isolated from biopsy tissue or blood.
• Using various molecular biology approaches, including Nanostring, single cell RNAseq, multiplex immunofluorescence, tissue spatial transcriptomic, to generate proteomic and transcriptomic data.
• Demonstrating independent problem solving and systematic data-driven experimental design and execution.
• Crafting and applying flow cytometry to immunophenotype cell populations using multicolor panels in various platforms and analyzing the data generated.
• Assessing new technologies/platforms that may be applied in current/future biomarker studies.
• Providing project update and experimental findings in oral and written communication.
• Authoring conference abstracts and peer-review publications.