Postdoctoral Fellow, Computational Chemistry

We are seeking a highly motivated computational chemist/computational biochemist to join the In Silico Discovery & External Innovation group at Janssen to help advance the computational modeling in the area oligonucleotide-based therapeutics. We are looking for applicants with a research background in computational chemistry or computational biology and who can apply computational skills to develop models on chemically modified oligonucleotides. We offer a collaborative and supportive environment for cutting-edge interdisciplinary research with high-impact opportunities to accelerate the oligonucleotides-based drug discovery. The Postdoctoral Scientist will: Develop, implement, and deliver models/workflows to predict efficacy and selectivity of chemically modified oligonucleotides. Compile consistent data sets for model training in collaboration with our RNA and Targeted Therapeutics group. Apply models/workflows to the design of chemically modified oligonucleotides that will be synthesized and tested experimentally through collaboration. Collaborate with external academic and industrial research partners. Tasks/Duties/Responsibilities Develop, implement, and deliver models/workflows to predict efficacy and selectivity of chemically modified oligonucleotides. Compile consistent data sets for model training in collaboration with our RNA and Targeted Therapeutics group. Apply models/workflows to the design of chemically modified oligonucleotides that will be synthesized and tested experimentally through collaboration. Read literature to gain background in siRNA, learn about existing computational techniques and stay up to date on the field of RNA computation. Communicate results to team members and collaborators Qualifications Required Minimum Education: PhD degree in in a relevant discipline such as Computational Chemistry, Chemistry, Computational Biology, Computational Sciences, Computer Science, Applied Mathematics, Bioinformatics. Experience with computational chemistry software and physics-based simulation of macromolecular systems, preferrable including nucleic acids. Experience with a scripting package or programming language such as Pipeline Pilot, Knime, or Python. Experience using Linux/UNIX. The ability to work individually (independently) as well as on a team. Strong oral and written communication, interpersonal, and collaboration skills. Research experience in one or more of the following areas: Molecular dynamics Developing machine learning models RNA structure and function Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-Pennsylvania-Spring House-Welsh & McKean Roads Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2105981100W