Principal Scientist, LNP Delivery, RNA & Targeted Therapeutics- South San Francisco, CA

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies, is recruiting for a Principal Scientist, LNP Delivery, RNA & Targeted Therapeutics within Therapeutics Discovery. This position is based in South San Francisco, CA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. RNA and Targeted Therapeutics is an organization within Therapeutics Discovery, committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with all six Janssen Therapeutic Areas (TA) discovery teams. Our mission requires strategic thinking, portfolio mindset and deep scientific expertise in several disciplines including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. We are currently seeking an outstanding individual to join our team as a Principal Scientist, LNP Delivery, RNA & Targeted Therapeutics. This role offers tremendous growth opportunity within a dynamic and science-driven organization. Key Responsibilities: As a dynamic project leader, drive and lead the discovery of novel lipid nanoparticle (LNP) based delivery technology and platform to support RNA-based therapeutics and vaccine, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions. Provide scientific direction, strategy and leadership for novel LNP discovery and formulation, process development, and optimization for in vivo delivery of mRNA, siRNA, gene therapy, and other therapeutic modalities. Supervise and lead a group of scientists to design and implement the experiments to discover and identify best-in-class LNP formulations to drive rapid advancement of RNA-LNP candidate selection. Participate in portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement Supervise and manage third-party, CRO and CMOs for external collaboration and outsourced work as needed. Critically evaluate experiment data and communicate scientific findings as verbal presentations and written reports; and provide updates on project status to Therapeutics Discovery leadership Team. Qualifications PhD degree in a synthetic organic, medicinal chemistry, physical chemistry or related scientific discipline is required. Postdoctoral experience with an emphasis on nucleic acid chemistry and nanoparticle-based delivery is preferred At least 6 years of experience in the biopharmaceutical industry with proven track record of leading innovative oligonucleotide discovery projects is strongly preferred. Prior experience with oligonucleotide delivery and/or LNP technologies, especially in LNP delivery of mRNA as vaccine/therapeutics, is preferred. Proven experience as a project leader and managing teams in a biopharmaceutical or biotech industry is preferred. Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and/or presentations at major national meetings is preferred. Excellent communication and interpersonal skills. Excellent prioritization and organization skills. Ability to collaborate across teams in a matrix environment is required This position is located in South San Francisco, CA, and may require up to 10% travel At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional, and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. IND7 Primary Location United States-California-South San Francisco-260 E. Grand Avenue Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2206036215W