Principal Scientist, Translational PK PD, Preclinical Sciences and Translational Safety

Janssen Research & Development, a Johnson & Johnson Company is recruiting for a Principal Scientist, Translational PK/PD in Preclinical Sciences and Translational Safety department to be based in Spring House, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. The translational PK/PD group within the department of Preclinical Sciences and Translational Safety is seeking a highly motivated Scientist to support PK/PD characterization informing the discovery and development of novel biologics through FIH across many therapeutic areas (TA) including oncology, immunology, metabolic diseases, neurology, and infectious diseases. Key Responsibilities: Apply target and disease biology, and PK/PD concepts to design and drive stage appropriate PK/PD strategies and experiments including target engagement, receptor occupancy, pharmacokinetic and biodistribution studies and other relevant ADME studies to improve scientific understanding, and support decisions on the design of novel biologics and lead candidate selections. Collaborate with cross-functional teams including discovery, biophysics, toxicology, and bioanalytical groups and others, to ensure knowledge exchange and integration for the success of the programs. Represent translational PK/PD function on project teams starting from early discovery through IND/CTA filing for various biologic modalities. Independently conducts NCA, compartmental PK/PD, and/or PBPK analysis to derive first in human and efficacious dose projections. Work in close collaboration with pharmacometrics to develop and implement mechanistic based PK/PD approaches. Accountable to determine FIH doses, write and/or review technical reports, interact with global regulatory agencies, and be involved in drafting preclinical PK and related sections in an IND or CTA. Perform platform investigations on novel biologic modalities (bispecifics, cell and gene therapy) from building data libraries and conducting meta-analyses using fit-for-purposes. Present findings in scientific conferences and publish research work in high quality and impact journals. Qualifications Education: A PhD in Pharmaceutical Sciences, Pharmacology, Immunology, or related degree with 0-2 years of post-doctoral research or experience in pharmaceutical industry. Experience and Skills: Required: 5 years of experience in pharmaceutical / biotech / CRO industry is required. Preferred: Extensive knowledge and research experience in elucidating PK, PK/PD and related properties for large molecule therapeutics is preferred. Strong ability to understand complex mechanistic PK/PD models is required. Hands on experience with at least one commonly used software tools (Eg: Phoenix WinNonlin, Monolix, or others) is preferred. Strong publication record is highly preferred. Excellent communication and proven ability to work with cross-functional teams is preferred. At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com. Primary Location United States-Pennsylvania-Spring House-Welsh & McKean Roads Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2206027921W