Senior Associate Scientist, Proteomics

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Associate Scientist, Proteomics, for our site in Cambridge, MA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. Do you want to use your hard earned skills to make a difference in the lives of patients? This candidate will join the Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery, to develop and apply groundbreaking approaches to proteomic screening and analysis. This effort will support the identification and development of small and large molecule therapeutics for diseases within Oncology, Immunology, Infectious Diseases, Neuroscience, and Cardiovascular and Metabolic Diseases. You will work in an exciting, interdisciplinary environment, overlapping the different stages of the discovery pipeline, by interacting with several internal and external organizations. You will implement proteomic experiments from proteomics sample prep through LC-MS acquisition and data analysis. With your help, we will drive development of medicines for our patients! Key Responsibilities: Generate samples for proteomics analysis from a variety of sources (immortalized cell lines, FFPE, fresh-frozen tissue, plasma/serum, etc.). Maintain multiple cell lines in both flasks and plates. Prepare assay plates and perform chemical treatments and perturbations. Apply high efficiency proteomics sample preparation methodologies across many experiment types (global proteomic profiling, immunoprecipitation, affinity, PTM analysis). Employ and troubleshoot several mass spectrometry acquisition modes (DIA, DDA, PRM) to acquire data required to answer experimental questions. Maintain and trouble shoot nanoflow liquid chromatography systems. Collaborate with colleagues from within the proteomics group to drive proteomics experiments across the drug discovery portfolio. Employ automation capabilities to enable the rapid generation of mass spectrometry datasets. Demonstrate creativity and apply novel approaches to solving scientific problems. Propose novel and practical ideas, aligned with scientific strategies and demands. Qualifications Education: A Bachelor’s degree or higher is required (in Analytical Chemistry, Biochemistry, Molecular Biology, Pharmacology, or a related field). Experience and Skills: A minimum of 2 or more years of proven experience in a proteomics laboratory setting, preferably in a drug discovery biotech or pharmaceutical environment. Experience with liquid chromatography (Waters nanoAcquity or Thermo EASY-nLC or UltiMate 3000) and mass spectrometry (Thermo QE, Exploris, Eclipse, Lumos or Bruker timsTOF) instrumentation is preferred. Minimum of 1 year experience with mammalian cell culture and treatment is required. Strong organizational skills and being able to handle several projects at a time is preferred. Excellent interpersonal skills with the ability to interact successfully with diverse colleagues is preferred. At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com. Primary Location United States-Massachusetts-Cambridge-MA Cambridge Binney Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2206050853W