Senior Scientist, Informatics - Spring House, PA or Cambridge, MA

Janssen Research & Development, LLC, a member of Johnson & Johnson's Family of Companies, is recruiting for a Senior Scientist, Informatics. This position can be located in Spring House, PA (Philadelphia area) or Cambridge, MA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, cardiovascular and metabolism, and pulmonary hypertension. Please visit http://www.janssenrnd.com for more information. The Therapeutics Discovery organization within Janssen R&D is continuing to build key scientific expertise in computational and medicinal chemistry, screening, and pharmacology to partner closely with our outstanding therapeutic area scientists to develop groundbreaking new medicines in the areas of Oncology, Immunology, Neuroscience, Cardiovascular, and Infectious Diseases. We are seeking creative, self-motivated informatics scientists/data scientists to join our In Silico Discovery team to bring their expertise to exciting efforts in drug design across both small molecule and alternative platforms. Join an enthusiastic, diverse, and global community of internal scientists committed to bringing innovative new medicines to patients. We are expanding our capabilities in informatics across multiple drug discovery platforms. These include, but are not limited to, parallel medicinal chemistry (PMC), targeted protein degradation, high-throughput screening (HTS), DNA-encoded library (DEL) screening, peptide-display discovery, and bioinformatics support for RNA-based therapeutics. As a Senior Scientist in the Informatics group, you will: Develop multidimensional data visualizations from multiple internal and external sources, including chemical structures, biological assay data, and other experimental results to discover new trends and enable improved decision-making in discovery projects. Develop workflows, scripts, and tools, including library enumeration, building-block mining, similarity searching, clustering and other methodologies to facilitate the discovery, design, and selection of molecules with improved drug-like properties Assess historical success rates of screening platforms, compound collections, and encoded libraries, and use that data to accelerate the drug discovery process by designing new libraries and screening strategies. Design databases and data processes to support screening modalities, including encoded libraries. Closely collaborate with other teams within Janssen, including computational chemists, ML/AI scientists, IT, medicinal chemists, and focused chemistry and biology discovery technology groups. Mentor junior scientists, fostering their development Qualifications PhD in computational chemistry, data science, or a related field is required A minimum of 3 years’ of industrial experience is required Extensive hands-on experience in cheminformatics (ie. chemical descriptors, similarity, diversity, SAR analysis, properties, library enumeration, design, chemical transformations, etc.) is preferred. Hands-on experience with large-scale data mining and analysis, including structured and unstructured data sources, is preferred. Experience in the design and enumeration of chemical libraries, including DEL, is preferred. Experience with fingerprint- and shape-based similarity searching is preferred. Experience with bioinformatics and RNA-based therapeutics is preferred. Proficiency with one or more programming, scripting, or querying languages is required. Examples may include Python, Jupyter Notebooks, Java, Pipeline Pilot, or SQL. Expertise in generating data visualizations in tools like Spotfire, Vortex, Tableau, DataWarrior is required. Familiarity with computational chemistry approaches such as molecular modelling, docking, pharmacophore analysis is preferred. Familiarity with the application of machine learning (ML)/artificial intelligence (AI) techniques to drug discovery is preferred. Excellent written and oral communication skills are required. This position will be based in either Spring House, PA or Cambridge, MA and may require approximately 10% travel. At Johnson & Johnson, we’re on a mission to change the trajectory of health for humanity. That starts by creating the world’s healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional, and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work. For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. IND7 Primary Location United States-Pennsylvania-Spring House-Welsh & McKean Roads Other Locations North America-United States-Massachusetts-Cambridge Organization Janssen Research & Development, LLC (6084) Job Function R&D Requisition ID 2206023943W