Senior Scientist- mRNA Vaccine Development BioChemistry and Structure

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Senior Scientist, mRNA Vaccine Development, RNA Biochemistry and Structure

Role Summary

We are looking for a Senior Scientist whose work will focus on RNA biochemistry and structural investigation for the Upstream Development Group within Early Bioprocess Development at VRD in Pearl River, NY.  The incumbent will work with the upstream mRNA drug substance team to support various efforts on molecular biology and RNA biochemistry.  A strong, hands-on background in all aspects of molecular biology is required, including in vitro transcription, RNA biochemical and structural analysis, molecular cloning, and plasmid construction. There would be special interest in candidates with a background in SHAPE and other forms of RNA analysis.  The incumbent would be joining a team of scientists well-versed in mRNA production and characterization, and would be expect to both support and innovate efforts on multiple fronts.

ROLE RESPONSIBILITIES

The primary responsibility would be to support efforts in molecular biology and RNA biochemistry/structure work in the group.

The incumbent should have a broad and strong understanding of all aspects of molecular biology, including plasmid design, biochemical and structural assays for RNA, and nucleic acid characterization for quality and purity

In addition to the above, the ideal candidate would have hands on experience in performing and analyzing nucleic acid sequencing in general, in the context of RNA structural tools, i.e. SHAPE or other affiliated techniques

As well as working with the mRNA team, the incumbent will be working closely with several other teams within and outside of VRD, as well as leading innovation efforts on their own

Data documentation will be performed in a timely and compliant manner, and data presentation will occur within the group, to project teams and at the departmental level.

BASIC QUALIFICATIONS

Ph.D. in Molecular Biology, Biochemistry, or related discipline and 0-2 years experience

Proven molecular biology and RNA biochemistry/structural skills

Experienced in the design and production of plasmid DNA and other forms of in vitro transcription templates

Command of analytical techniques such gel/capillary gel electrophoresis, fragment analyzer, ddPCR, nucleic acid analysis (Sanger, NGS, Nanopore, etc.)

Ability to design, organize and execute complex experiments

Ability to plan experimental workflows for multiple experiments

Ability to work independently

Collaborates in a team environment

Compiles, organizes and evaluates data

Has experience in preparing making comprehensive presentations

OTHER DETAILS
Relocation support available

Work location is onsite

Employee Referral eligible

#LI-PFE

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Research and Development