Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
We are looking for a Sr. Associate Scientist who contributes to DNA template production workstream as part of the strain change effort at Pfizer. This position will be within Early Bioprocess Development, VRD, Pearl River NY. The incumbent will contribute to a program dedicated to the production of mRNA for use as a vaccine entity. Major responsibilities of the role are the execution and record-keeping of manufacture of DNA template at the milligram/gram scale. In addition to the chief responsibility of DNA template production, the incumbent would also function in purification process in-vitro transcription and analytical capacities as necessary. A background in molecular biology, biochemistry or biochemical engineering would be components of a successful candidate’s background.
The incumbent’s primary assignment is manufacturing DNA template using enzymatic reactions/bacterial culture for mRNA production.
Manufacture will be at milligram/gram scale, and will generally require the use of biochemical reactor systems
Execution and relevant production data will be formally recorded in accordance with established recording procedures and systems in a timely and compliant manner
The incumbent will be expected to perform other activities as necessary, including analysis, purification, in vitro transcription, formulation, and DNA work
Fully documents experimentation in laboratory notebooks in a timely and compliant manner.
Works irregular hours (weekends and outside of 9-5 format) as experiments warrant
Bachelor's degree in Biochemistry, Molecular Biology, biochemical engineering , Biotechnology or related discipline with up to 2 years of experience
Familiar with the design and execution of E coli culture, plasmid DNA purification and enzymatic DNA amplification reaction.
Familiar with analytical techniques such as agarose gel electrophoresis, DNA quantification, Nanopore sequencer, fragment analyzer, and HPLC
Ability to work on familiar tasks with limited instruction and supervision
Collaborates in a team environment
Compiles and organizes data
Has experience in preparing and making summary presentations
Ability to lift 50LBS and could move objects between labs. Detailed understanding of the scientific subject matter an ability to make scientific judgments and to perform data analysis.
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
The work requires a flexible work schedule to properly perform experiments to meet the project timeline. This may involve the necessity of working outside of core hours and on weekends.
Relocation support available
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development
Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. We make medicines and vaccines that help people when they are sick and prevent them from getting sick in the first place. Every day, our colleagues work in developed and emerging markets to ...