Postdoctoral Fellow, Computational Biology in Cancer - Chan Lab at Memorial Sloan Kettering Cancer Center

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Job details

The Chan Lab in the Human Oncogenesis & Pathogenesis Program at Memorial Sloan Kettering Cancer Center is seeking a highly motivated and successful individual with a back ground in computational biology . The Chan Lab is a new, multidisciplinary group develop ing machine learning methods using cutting-edge single-cell and cell-free sequencing as well as spatial imaging to study how cell fate decisions mediate metastasis and acquired resistance across different cancer types , and how epigenetic and environmental factors guide this process . A central focus of our work is to quantify lineage plasticity (the capacity to switch to non- canonical phenotypes ) to gain insight into the underlying molecular machinery and identify new drug targets to constrain or even reverse plasticity . Representative publications include :

• Chan , et al. Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Science , 2022.

• Chan , et al. Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer Cell , 2021 .

• Schoenfeld, Chan , et al. Tumor analyses reveal squamous transformation and off-target alterations as early resistance mechanisms to first-line osimertinib in EGFR-mutant lung cancer. Clinical Cancer Research , 2020 .

• Offin , Chan , et al. Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes. Journal of Thoracic Oncology , 2019 .

• Chan , et al. Topology of viral evolution. PNAS , 2013 .

• Singh, Chan , et al. Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma. Science , 2012 .

This position will involve a mixture of methodological development and analysis of large-scale datasets of patient samples from a leading cancer center, as well as time-series analysis of sophisticated preclinical models through highly collaborative research . This position will require developing and maintaining software packages, assisting or leading in manuscript writing, engaging in a vibrant scientific community through regular work-in-progress and lab meetings, and other academic activities. For further information, please visit the lab website at https://www.joechanlab.org .

The ideal candidate should have:

• A PhD in Computational Biology, Bioinformatics, Computer Science, Statistics, or a related field

• P roficie ncy in Python and R

• Prior experience in computational biology

• Ability to engage in independent thinking

• Excellent skills in writ ten and verbal communication

• Collegiality as a team member and a willingness to mentor other trainees

• At least 1 published first-author manuscript

If you have any questions about this job opportunity, please contact:

Dr. Joseph M. Chan , MD, PhD

[email protected]

Please include a cover letter, brief statement of prior research experience and research interests, CV, and contact information for three references in your application submission.

Salary: $70,000-$ 85 , 000 (depending on postgraduate experience)

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