Senior Principal Scientist, Lab head - NMR and Mass Spec

Pfizer

4.1

(94)

Groton, CT

Why you should apply for a job to Pfizer:

  • 4.1/5 in overall job satisfaction
  • 4.6/5 in supportive management
  • 78% say women are treated fairly and equally to men
  • 79% would recommend this company to other women
  • 81% say the CEO supports gender diversity
  • Ratings are based on anonymous reviews by Fairygodboss members.
  • 23-25 Week Maternity Leave (Fully paid for birth parents)
  • Family building benefits include $35,000 fertility services + $25,000 adoption and surrogacy services
  • Pfizer is a founding member of Healthcare Businesswomen's Association Gender Parity Collaborative
  • #4911334

    Position summary

    at Pfizer. We are looking for ambitious Analytical Chemists, eager to see their work led to important new medicines and scientific breakthroughs, to join our Analytical Technologies and Compound Management (ATCM) team. As an NMR-MS Senior Principal Scientist and Lab Head you will lead the ATCM NMR-MS group which leverages small molecule NMR and Mass Spectrometry to drive the design and synthesis of Pfizer's medicinal chemistry portfolio. You will work closely with medicinal chemistry to elucidate compound structures and stereochemical determinations as well as solution conformation analyses to drive stage-gate transitions for the Pfizer Discovery Portfolio. You will set the strategy for the ATCM NMR-MS group and represent ATCM in establishing an overall plan for maintaining fleet of NMR and Open Access NMR/Mass Spec/Spectroscopy instruments. You will develop new methods for using NMR and Mass Spec to drive drug discovery and you will represent the NMR-MS group in internal/external presentations and publications.

    How You Will Achieve It

    • Set the strategy for ATCM Small Molecule NMR-MS to support the Pfizer East Coast Medicinal Chemistry and Design portfolio.

    • Lead, mentor, and develop a group of NMR spectroscopists and Mass Spectrometrists.

    • Contribute to the strategy of ATCM as part of the ATCM Leadership Team.

    • Improve and maintain the fleet of small molecule NMR and MS instrumentation.

    • Characterize and elucidate the structure of small molecules, nucleic acids, macrocycles, and peptides using advanced 1D and 2D NMR techniques.

    • Perform conformational analyses to establish molecular solution conformations to drive lead compound optimizations.

    • Contribute to the development of new technology in ATCM such as microscale high-throughput NMR, high-throughput and flow reaction monitoring by NMR, automated structure verification, High Resolution and Acoustic Ejection Mass Spectrometry.

    • Identify and apply other analytical techniques beyond NMR to solve chemical or molecular-structural challenges.

    • Support and contribute to the evolution of the ATCM Group's culture of teamwork and scientific excellence.

    Qualifications

    Must-Have

    • 15+ years of industry experience with a bachelor's degree, 11+ years of experience with a Master's degree or 8+ years of experience with a Ph.D. in Chemistry, Biochemistry, Biophysics or a related field.

    • Recognized for using a high level of scientific judgment, independent and creative with a strong track record of applying novel experimental approaches for problem solving to support projects.

    • Recognized as an expert in identifying and developing scientific strategies to support mid- and long-term goals for the department.

    • Recognized as a mentor with a strong track record of coaching others.

    • Track record of teamwork/collaboration within multi-disciplinary matrix teams leading to delivery of project objectives.

    • Proven track record of success in small molecule organic structure elucidation and small molecule solution conformation determination.

    • Expert knowledge of NMR and MS instrumentation (both hardware and software) and the ability to maintain instrumentation and automation (Bruker, JEOL, Waters, Sciex).

    • Expertise in NMR software packages: ACD, MestreLab and MSpin.

    • Strong communication skills and a demonstrated ability to create and strongly contribute to independent research projects.

    • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop, and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

    Nice-to-Have

    • Experience with other analytical methods and a good knowledge of organic chemistry.

    • Experience with computational chemistry, computer programming or information technology.

    • Experience with Gaussian and DFT calculations.

    PHYSICAL/MENTAL REQUIREMENTS

    • Position will require working in the lab, operating automated equipment, lifting, sitting, standing, walking, bending and the ability to perform mathematical calculations and solve complex technical problems.

    PHYSICAL/MENTAL REQUIREMENTS

    • Position will require working in the lab, operating automated equipment, lifting, sitting, standing, walking, bending and the ability to perform mathematical calculations and solve complex technical problems.

    NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

    • NA

    Other Job Details:

    • Last Date to Apply for Job: 24 MAY 2024

    • Eligible for Employee Referral Bonus

    • Eligible for Relocation Assistance

    Work Location Assignment: On Premise

    On Premise colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site

    The annual base salary for this position ranges from $117,300.00 to $195,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

    Relocation assistance may be available based on business needs and/or eligibility.

    Sunshine Act

    Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

    EEO & Employment Eligibility

    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

    Research and Development

    Why you should apply for a job to Pfizer:

  • 4.1/5 in overall job satisfaction
  • 4.6/5 in supportive management
  • 78% say women are treated fairly and equally to men
  • 79% would recommend this company to other women
  • 81% say the CEO supports gender diversity
  • Ratings are based on anonymous reviews by Fairygodboss members.
  • 23-25 Week Maternity Leave (Fully paid for birth parents)
  • Family building benefits include $35,000 fertility services + $25,000 adoption and surrogacy services
  • Pfizer is a founding member of Healthcare Businesswomen's Association Gender Parity Collaborative