Pursue work I love, or work to support my loves and interests?

Hi FGB community, within the next week, I may receive an offer for a great position. It would involve relocating, a lower salary, leaving a supporting workplace, and a return to a career track about which I care deeply. I need some feedback on if this would be a good move, and tangentially, the cost of living in central Virginia (Lynchburg) to see if the salary will support my desired lifestyle and work/life balance. A little background: About a year ago, I left a non-profit job in museums. I liked the job and the responsibilities but the environment was toxic and there was a history of mismanagement that didn't look like it would resolve anytime soon. I moved into my first corporate position with a great employer that offers amazing benefits, competitive wages, paid overtime, tuition reimbursement, etc. There are ample advancement opportunities with the company - rare in small and medium non-profits. Environment is much more supportive and co-workers are great. But.... I just don't love the work right now. The expected offer is for a promising job at a medium non-profit but the salary will be $45,000. In my current role, with the expected overtime, I'll likely make around $60,000 this year. Pro's in Virginia: -Lower cost of living -Closer to competitive English horseback riding (my primary hobby/fitness pursuit) -Closer to more family Con's in Virginia: -2+ hours to major airport makes it difficult to travel -Small city with politics that oppose my personal position -Fewer advancement opportunities Any Virginia residents out there who can let me know if $45k will be sufficient? Any career counselors or gurus who can advise on some factors I should weigh more or less?