Hi All, I am looking for some advice. Sorry for length. I have been in the biopharma/medical device industry for 20 years, in various roles from customer service, tech support, sales, distribution management, program management, and operations management. I have really enjoyed most of my roles. My last role was working in operations to help commercialize a treatment for brain cancer that was in phase 3. I really enjoyed this role, the mission, and the company, and felt that I really had found my niche and what I was supposed to be doing. Unfortunately our clinical trial failed, and the company folded. I was on the job hunt for about 2-3 months, and I took a job as a Program Manager at a biotech manufacturing company. I've only been here about 2 months, but know it is not the right fit for me. I feel that I am not qualified for this job in terms of my technical/scientific knowledge. Everyone else in this role has advanced degrees and has been in the lab recently. I know they were a bit desperate to hire, as they made me a very generous offer and wanted an answer right away (next day!). They have had some turnover, and I am not getting a good vibe from the company. More important, I just don't think we are the right fit for each other. They need someone more technical with recent lab experience, and I haven't been in a lab in 20 years. I think it's vital to have this background to properly work with our clients. I made it very clear during the interview process (3 rounds) that most of my experience was on the commercial side, so I'm not sure where the disconnect was, and honestly not sure why they hired me. I often feel lost in meetings. It doesn't help that Covid started right when I started this job, so I literally went in to office day 1, and not since. And the very next week, my boss went out on medical leave, so I have not had any real guidance or training. I have not been assigned project/client of my own yet due to losing some business, which is a blessing in disguise, because I am not confident that I can do justice to this job. And it is clear that it is not the job I want. I want to work somewhere that is very patient and mission-focused, and this company is not that. Anyway, I am leaning towards resigning before we get any further, and before they assign me to a project which would make things ugly for both parties when I do leave. I have some leads for consulting and am looking at other positions. Bottom line, I've been working for 20 years, I know my strengths, I know what I'm good at, I know where I thrive, and this is not it. How should I approach this-I don't even have a boss to talk to! Should I resign via email and explain my reasons why? There is someone filling in for my boss. Should I have a conversation first and explain this (but to what end?) I now know exactly what I am looking for in my next position, and will focus on companies and opportunities that provide this. Thanks so much for any advice!