Yes, I changed careers (twice), and, NO, I didn't regret it or go back to the original career.
I went from a nurse to an EHR (Electronic Health Record) instructor, teaching clinicians how to use their medical software to document patient care. Then, I changed again because I wanted to build the EHR documentation and support it (Systems Analyst). All of these careers were within healthcare and much of what I became expert at overlapped in each career change.
The first time I changed careers from a nurse to an instructor of medical staff, it was from something requiring a higher level of education/knowledge to something technically lower in skill. Since the positions were for consulting jobs, the pay was a lot better than nursing with less stress. I was under contract, and the jobs were in different locations across North America. I enjoyed the work, the paid travel and hotels, plus the frequent flyer miles were an added bonus.
The second time I changed careers to build EHR documentation, I had to learn the flipside of what I had been teaching, so technically I went from a technically lower skill to something requiring a higher level of knowledge. The pay was actually a bit lower and salaried, but more steady, and the benefits were great. I had children in school and I needed to be home more.
When I changed careers each time, I learned how to do the new jobs on the job and with pay. It was well worth it for me to shake it up, periodically, to adjust my job to my life instead of the other way around. I planned on the last career change as I was winding up a contract for my last consulting job.
Life is about change. What works for you may not work for someone else. You have to be willing to take a risk when you make major changes, and also be willing to count on yourself. I bet everything on me, and I also served as my own backup - just in case things didn't go as I expected. It helps to really like what you do and what you want to do in order for you to give it your best shot, too. Good (skills!) luck.
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